The Detroit Lions hit the road to face the Washington Commanders in a late-afternoon Week 10 matchup that promises physical play and playoff implications for both sides. Detroit continues to assert itself as one of the NFC’s most balanced and resilient teams, while Washington looks to protect home turf and regain momentum with a statement performance.

The Lions’ offensive core, led by Jared Goff and Amon-Ra St. Brown, has been firing on all cylinders, while their defense has quietly become one of the toughest against the run. On the other hand, Washington’s defense — anchored by its aggressive front line — will look to disrupt Goff’s rhythm early and create turnover opportunities that could swing the outcome.

Here’s everything you need to know about the Lions vs Commanders showdown, including kickoff details, viewing information, and betting insights.

BEO betting odds are showing Detroit as the slight favorite on the road ::: Discover the latest Bet Entertainment Odds predictions for this market.

When is the Detroit vs Washington game?
The Detroit Lions take on the Washington Commanders on Sunday, November 9, 2025, during Week 10 of the NFL regular season.

What Time Will the Game Start?
Kickoff is set for 4:25 p.m. (ET) at FedExField in Landover, Maryland.

Where Will It Be Held?
The matchup will take place at FedExField, where Washington hopes to use its home-field energy to contain one of the league’s most physical and efficient teams.

Which Team is Favored to Win?
The Lions enter as -2.5 favorites, reflecting their recent dominance in the trenches and consistency on both sides of the ball. Detroit’s offensive balance — powered by David Montgomery and Jahmyr Gibbs — gives them flexibility against a Commanders defense that can struggle to defend multi-dimensional attacks.

The Commanders, however, shouldn’t be counted out. If Sam Howell can find early rhythm and the defense forces Detroit into third-and-long situations, Washington could turn this into a slugfest that goes down to the wire.

Where Can I Watch the Detroit vs Washington game?
Fans can catch the action live on FOX, with streaming options available via NFL+, YouTube TV, and FuboTV.

BEO Odds Insight
According to Bet Entertainment Odds, Detroit opens as a -2.5 favorite, with the over/under set at 43.5 points. Early bettors lean toward the Lions on the spread, while sharps are split on the total, anticipating a defensive battle. Prop highlights include Amon-Ra St. Brown over 6.5 receptions (-120) and Terry McLaurin anytime TD (+135).

Stay tuned with Bet Entertainment Odds for live odds updates, betting analysis, and real-time insights as the Lions and Commanders clash in a pivotal Week 10 matchup.