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The rivalry between the Los Angeles Rams and San Francisco 49ers has been brewing since the 1970s.
In addition to being NFC West rivals, the teams represent the north (49ers) and south (Rams) of California, causing much division across the state.
As the teams play each other twice every season, they often shape each other’s shot at the divisional title and playoff seeding.
As many fans will be eager to secure bragging rights this season, you can guarantee an electric atmosphere when the teams meet this October.
Read on to learn more about the upcoming game between the Los Angeles Rams and San Francisco 49ers, including its date, time, venue, and broadcast information.
When is the Los Angeles Rams vs the San Francisco 49ers?
The Los Angeles Rams will play against the San Francisco 49ers on Thursday, October 2, 2025.
What Time Will the Game Start?
The game between the NFC West rivals is expected to start at 8:15 p.m. (ET) and 5:15 p.m. (PT).
Where Will It Be Played?
The Los Angeles Rams will have the home-field advantage during their first meeting against the San Francisco 49ers this season.
The Rams will host the 49ers at SoFi Stadium in Inglewood, California, and the energy and support from the home crowd could inspire their players and intimidate the visiting team.
What Team is Most Likely to Win?
The LA Rams are tipped to win the upcoming game against the San Francisco 49ers, as they have won the last three matchups against their rivals.
As the Rams have the home-field advantage and dominated the 49ers recently, they are likely to enter the game with considerable confidence and determination.
As of mid-September 2025, the Rams and 49ers are both undefeated, meaning fans can expect a competitive, close game this October.
The Rams’ success is partially due to the elite performance of quarterback Matthew Stafford, as he is a natural leader with fantastic control of the team’s offense. Also, he’s backed up by talented offensive players, such as wide receivers Puka Nacua and Davante Adams.
The defensive line has been transformed, as edge rusher Byron Young is a force to be reckoned with on the field, as he can place considerable pressure on the opposition’s quarterbacks.
Yet, the San Francisco 49ers shouldn’t be underestimated, as they will have their sights set on the NFC West title.
The team will be fueled by revenge due to three consecutive defeats by the Rams and will do everything in their power to prevent a fourth loss.
The 49ers have top-tier talent on their side to defeat the Rams at their home stadium. For instance, Brock Purdy might struggle to rival Stafford for passing, but he’s a strong leader who knows how to avoid turnovers from the Rams’ dominant offense.
He’s supported on the field by dual threat running back Christian McCaffrey, who is a dependable passer with a superb running game.
Plus, the Rams’ defense could struggle when facing the 49ers’ elite receiving corps of George Kittle and Ricky Pearsall.
Where Can I Watch the Los Angeles Rams vs the San Francisco 49ers?
You can watch the LA Rams play against the San Francisco 49ers on Prime Video on October 2, 2025, as it is part of the platform’s Thursday Night Football deal.
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